Description: Abiraterone is a medication used in the treatment of advanced prostate cancer. It belongs to a class of drugs known as androgen biosynthesis inhibitors and is specifically indicated for use in combination with other therapies for metastatic castration-resistant prostate cancer (mCRPC).

Mechanism of Action: Abiraterone works by inhibiting an enzyme called CYP17, which is involved in the production of androgens (male hormones). By blocking this enzyme, abiraterone reduces the production of androgens, including testosterone, which fuel the growth of prostate cancer cells.

Indications:

1. Metastatic Castration-Resistant Prostate Cancer (mCRPC): Abiraterone is primarily prescribed for individuals with mCRPC, a form of advanced prostate cancer that no longer responds to hormonal therapies designed to lower testosterone levels.
2. Combination Therapy: It is often used in combination with prednisone or prednisolone to maximize its effectiveness and manage potential side effects.

Administration:

• Abiraterone is typically taken orally in the form of tablets.
• It is usually taken on an empty stomach or with a light meal.
• The prescribed dosage and schedule are determined by the treating healthcare professional.

Monitoring:

• Patients taking abiraterone are regularly monitored through blood tests to assess the levels of prostate-specific antigen (PSA) and to check for potential side effects.

Side Effects: Common side effects of abiraterone may include fatigue, joint swelling or discomfort, high blood pressure, fluid retention, hot flashes, and gastrointestinal symptoms. It’s important for patients to report any side effects to their healthcare provider.

Precautions:

• Abiraterone is not recommended for use in women, especially pregnant women, as it may cause harm to a developing fetus.
• Regular monitoring of liver function is often required, as abiraterone may affect liver enzymes.

Duration of Treatment: The duration of abiraterone treatment depends on the individual’s response to the medication and the progression of the cancer. Treatment plans are typically discussed and adjusted by the healthcare team.

Consultation with Healthcare Professional: Abiraterone is a prescription medication, and its use should be discussed thoroughly with a healthcare professional. It is important for patients to inform their healthcare provider about their medical history, other medications, and any existing health conditions before starting treatment.

Abiraterone has been shown to be effective in slowing the progression of advanced prostate cancer and improving overall survival. However, its use involves careful monitoring and management of potential side effects to ensure the best possible outcomes for the patient.