Chemical name: (8R,9S,10R,13S,14S)-10,13-dimethyl-6-methylidene-7,8,9,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,17-dione
Formula: C20H24O2
Anabolic activity index: not a steroid
Androgenic activity index: not a steroid

AROMASIN 25mg – DRAGON PHARMA

Description: AROMASIN 25mg is a medication manufactured by Dragon Pharma. It is available in tablet form, with each tablet containing 25mg of the active substance Exemestane. Exemestane is classified as an aromatase inhibitor, primarily used in the treatment of hormone receptor-positive breast cancer in postmenopausal women.

Active Substance:

• Exemestane: Exemestane is a steroidal aromatase inhibitor that selectively inhibits the enzyme aromatase, which is responsible for the conversion of androgens into estrogens in peripheral tissues, including adipose tissue, muscles, and breast cancer tissue. By inhibiting aromatase, Exemestane reduces estrogen levels in the body, which can slow down the growth of hormone receptor-positive breast cancer.

Form:

• 100 pills x 25mg: This indicates that each pack of AROMASIN 25mg contains 100 tablets, with each tablet containing 25mg of Exemestane.

Uses: AROMASIN 25mg (Exemestane) is primarily prescribed for the following purposes:

1. Breast Cancer Treatment: It is used as adjuvant therapy in postmenopausal women with hormone receptor-positive early breast cancer after completion of two to three years of tamoxifen therapy. It is also used for the treatment of advanced breast cancer in postmenopausal women whose disease has progressed following tamoxifen therapy or other endocrine therapies.
2. Breast Cancer Prevention: In some cases, Exemestane may be used for breast cancer risk reduction in postmenopausal women at high risk of developing breast cancer.

How to Use: AROMASIN 25mg tablets are taken orally, usually once daily, with or without food. The dosage and duration of treatment depend on the patient’s medical condition, response to treatment, and individual factors. It is important to follow the prescribing healthcare provider’s instructions carefully.

Storage Conditions: AROMASIN 25mg tablets should be stored at room temperature, away from moisture, heat, and direct sunlight. It is essential to keep the medication out of reach of children and pets.

Mechanism of Action: Exemestane works by irreversibly binding to the active site of the aromatase enzyme, leading to its inactivation. This prevents the conversion of androgens into estrogens, resulting in reduced estrogen levels in the body. Lower estrogen levels can slow down the growth of hormone receptor-positive breast cancer cells.

Precautions:

• Patients with a history of liver disease, osteoporosis, or cardiovascular disorders should use Exemestane cautiously and under the supervision of a healthcare provider.
• Regular monitoring of bone mineral density, lipid profiles, and liver function tests may be required during treatment with Exemestane.

Contraindications: AROMASIN 25mg is contraindicated in individuals with a known hypersensitivity to Exemestane or any component of the formulation. It should not be used in premenopausal women or in pregnant or breastfeeding women.

Drug Interactions: Exemestane may interact with certain medications, including tamoxifen, estrogen-containing therapies, and other drugs metabolized by cytochrome P450 enzymes. Patients should inform their healthcare provider about all medications they are taking to avoid potential interactions.

Side Effects: Common side effects of Exemestane may include hot flashes, sweating, fatigue, headache, insomnia, joint pain, and nausea. Other potential side effects include osteoporosis, cardiovascular events, and mood changes. Serious adverse reactions such as liver toxicity and allergic reactions may occur but are rare.

Patients should consult their healthcare provider for personalized advice and information regarding AROMASIN 25mg (Exemestane), including its uses, dosage, and potential side effects.