Chemical name: (8R,9S,10R,13S,14S)-10,13-dimethyl-6-methylidene-7,8,9,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,17-dione
Formula: C20H24O2
Anabolic activity index: not a steroid
Androgenic activity index: not a steroid

AROMASIN 25mg – PARA PHARMA

Description: Aromasin 25mg is a medication manufactured by Para Pharma. It contains the active substance exemestane, which belongs to a class of drugs known as aromatase inhibitors. Each package contains 50 pills, with each pill containing 25 milligrams of exemestane. It is commonly used in the treatment of hormone receptor-positive breast cancer in postmenopausal women.

Active Substance: The active substance in Aromasin 25mg is exemestane. Exemestane is a steroidal aromatase inhibitor that works by blocking the enzyme aromatase, which is responsible for converting androgens into estrogen in the body. By inhibiting aromatase activity, exemestane reduces the production of estrogen, which can help slow or stop the growth of hormone receptor-positive breast cancer cells.

Indications: Aromasin 25mg is indicated for the treatment of hormone receptor-positive breast cancer in postmenopausal women. It is used:

• Adjuvantly following surgery to reduce the risk of recurrence.
• In the treatment of advanced breast cancer that has spread to other parts of the body (metastatic breast cancer).
• In the prevention of breast cancer in high-risk postmenopausal women.

Mechanism of Action:

• Exemestane works by irreversibly binding to the aromatase enzyme, blocking its activity and preventing the conversion of androgens into estrogen.
• By reducing estrogen levels in the body, exemestane deprives hormone receptor-positive breast cancer cells of the estrogen they need to grow and proliferate.
• This can help slow or stop the progression of breast cancer and improve outcomes in postmenopausal women with hormone receptor-positive disease.

Administration:

• Aromasin 25mg tablets are taken orally with a glass of water.
• The recommended dosage for most patients is 25 milligrams once daily, preferably after a meal.
• Treatment duration and dosage may vary depending on the specific indication, disease stage, and individual patient response.

Dosage:

• The usual dosage of Aromasin 25mg is 25 milligrams taken once daily.
• Dosage adjustments may be necessary in patients with hepatic impairment or those who experience adverse effects.
• It is important to adhere to the prescribed dosage and regimen to achieve optimal treatment outcomes.

Monitoring:

• Patients taking Aromasin 25mg should undergo regular monitoring, including clinical assessments and laboratory tests, to evaluate treatment response and monitor for adverse effects.
• Monitoring may include assessments of bone density, lipid profile, and liver function, among other parameters.

Side Effects: Common side effects of Aromasin 25mg may include:

• Hot flashes
• Fatigue
• Sweating
• Joint pain
• Headache
• Insomnia
• Nausea
• Osteoporosis or bone fractures (with long-term use)

Precautions:

• Aromasin 25mg should be used with caution in patients with hepatic impairment or a history of osteoporosis.
• It may interact with other medications, and patients should inform their healthcare provider about all medications they are taking.
• Women of childbearing age should use effective contraception during treatment with exemestane, as it may cause harm to a developing fetus.

Consultation with Healthcare Professional:

• The use of Aromasin 25mg should be discussed thoroughly with a healthcare professional, typically an oncologist or breast cancer specialist.
• Patients should inform their healthcare provider about their medical history, existing health conditions, and any medications they are taking before starting exemestane therapy.

Aromasin 25mg, manufactured by Para Pharma, is a medication indicated for the treatment of hormone receptor-positive breast cancer in postmenopausal women. Its use involves careful monitoring and adherence to prescribed dosage and regimen to optimize treatment outcomes and minimize the risk of adverse effects.