Description: Austedo is an oral medication containing the active ingredient deutetrabenazine. It is manufactured by Teva Pharmaceuticals and is approved by the Food and Drug Administration (FDA) for the treatment of specific movement disorders associated with Huntington’s disease and tardive dyskinesia.

Indications: Austedo is indicated for:

• The treatment of chorea associated with Huntington’s disease, a genetic disorder that causes the progressive breakdown of nerve cells in the brain, leading to physical, cognitive, and psychiatric symptoms.
• The treatment of tardive dyskinesia, a condition characterized by repetitive, involuntary movements, typically of the face, tongue, and limbs, often resulting from long-term use of certain antipsychotic medications.

Mechanism of Action: Deutetrabenazine, the active ingredient in Austedo, works by inhibiting vesicular monoamine transporter 2 (VMAT2), a protein that regulates the uptake of neurotransmitters into synaptic vesicles. By inhibiting VMAT2, deutetrabenazine reduces the levels of dopamine and other neurotransmitters in the brain, thereby decreasing involuntary movements associated with Huntington’s disease and tardive dyskinesia.

Dosage and Administration: Austedo is taken orally, with or without food. The dosage is individualized based on the patient’s condition, response to treatment, and tolerance. It is important to follow the dosing instructions provided by the healthcare provider. Typically, the dosage is gradually increased to find the optimal balance between therapeutic effects and side effects.

Precautions:

• Austedo should not be used in patients with untreated or inadequately treated depression, suicidal thoughts, or hepatic impairment.
• Patients should be monitored for signs of depression, suicidal thoughts, and other psychiatric symptoms during treatment.
• Austedo may interact with other medications, so it is important to inform the healthcare provider about all medications, supplements, and herbal products being taken.
• Caution is advised in patients with a history of heart disease or QT prolongation.

Adverse Reactions: Common adverse reactions associated with Austedo may include drowsiness, dry mouth, diarrhea, fatigue, and insomnia. Serious side effects can include depression, suicidal thoughts, neuroleptic malignant syndrome, and QT prolongation. It is essential to report any unusual or severe symptoms to a healthcare provider immediately.

Storage: Austedo should be stored at room temperature, away from moisture, heat, and direct sunlight. Keep the medication in its original container and out of reach of children. Unused or expired medication should be disposed of properly according to local regulations.

Disclaimer: The information provided here is for informational purposes only and does not constitute medical advice. Always consult with a healthcare professional regarding any questions or concerns about your condition or treatment options.