What medical condition is Edaravone (Daiichi Sankyo) used to treat?

Edaravone, marketed under the brand name Radicava, is a medication that is used to treat Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig’s disease. ALS is a progressive neurodegenerative disease that eventually leads to severe muscle weakness and paralysis. It affects the nerve cells in the brain and the spinal cord responsible for controlling voluntary muscle movement.

Edaravone is an intravenous therapy that helps to slow the decline in physical function among ALS patients by reducing oxidative stress caused by the accumulation of free radicals. It works as an antioxidant that targets harmful molecules and protects cells from oxidative damage, reducing cell death, and further slowing down the progression of ALS.

Edaravone is not a cure for ALS, but it can slow the decline in physical function, improve daily functioning and extend the life of patients. It is administered under the supervision of a healthcare professional in a hospital or clinic setting.

What is the mechanism of action of Edaravone (Daiichi Sankyo)?

Edaravone, marketed under the brand name Radicava, works by reducing oxidative stress, which is thought to be a major contributor to the progression of Amyotrophic Lateral Sclerosis (ALS)

Oxidative stress occurs when the body produces an excess of free radicals, highly reactive molecules that can cause damage to cells, proteins, and DNA. In people with ALS, oxidative stress leads to damage to motor neurons, which are the nerve cells in the brain and spinal cord responsible for controlling muscle movements. This damage ultimately leads to the loss of muscle function and paralysis.

Edaravone works by acting as an antioxidant that targets the free radicals and protects cells from oxidative damage. It also helps to scavenge these harmful molecules before they cause further damage to the body’s tissues. By reducing oxidative stress, Edaravone may help to slow down the progression of ALS and improve physical function in patients with the disease.

However, the exact mechanism by which Edaravone works is still not fully understood and is the subject of ongoing research.

How is Edaravone (Daiichi Sankyo) taken?

Edaravone, marketed under the brand name Radicava, is administered through an intravenous (IV) infusion. It is given over a period of 60 minutes, usually every day for the first 14 days, followed by a two-week break before the starting of another 14-day treatment cycle.

During the infusion, patients are closely monitored by healthcare professionals to ensure they do not experience any adverse reactions. If side effects occur, the infusion may be slowed down or stopped and the patient may be given other medications to manage the symptoms.

Before starting treatment with Edaravone, patients undergo a baseline medical examination, including blood tests, liver function tests, and a neurological exam, to evaluate their overall health and to ensure they are eligible for the treatment. After completing the treatment cycles, patients will need to be re-evaluated by their healthcare team.

It is important to note that Edaravone is only available through authorized infusion centers and should only be administered under the supervision of a healthcare professional trained in its use.

Are there any known side effects of Edaravone (Daiichi Sankyo)?

Yes, there are known side effects of Edaravone (Daiichi Sankyo). Common side effects of Edaravone include:

– Bruising or swelling at the injection site
– Gait disturbance
– Headache
– Dizziness
– Nausea
– Itching
– Back pain
– Mouth ulcers
– Breathing problems

In rare cases, more serious side effects have been reported, including allergic reactions, confusion, and decreased platelet counts. Patients should inform their healthcare professional if they experience any new or unusual symptoms after starting treatment with Edaravone.

Additionally, Edaravone may interact with other medications, so patients should inform their healthcare professional of all medications they are taking before starting treatment. It is important to discuss any concerns about possible side effects or medication interactions with a healthcare professional before starting treatment with Edaravone.