Entresto (sacubitril/valsartan) is a combination medication used to treat heart failure with reduced ejection fraction (HFrEF). This medication is produced by Novartis Pharmaceuticals and is available in tablet form.

Uses:
Entresto is mainly used to treat HFrEF in patients who are not responding well to other therapies. This medication can also be used to reduce the risk of cardiovascular death and hospitalization due to heart failure in patients with chronic heart failure.

HOW TO USE:
Entresto tablets should be taken orally with or without food. The tablets should not be crushed, chewed, or broken. The dosage and frequency of the medication may vary based on the patient’s condition and response to the medication.

Dosage:
The recommended dosage of Entresto is 97/103 mg two times daily, which can be increased to 202/208 mg two times daily. The starting dosage of the medication may vary based on the patient’s medical condition, tolerance, and other medications taken.

Mechanism of action:
Entresto is a combination of sacubitril and valsartan. Sacubitril is an angiotensin receptor-neprilysin inhibitor (ARNI) that works by blocking neprilysin, an enzyme that breaks down natural peptides such as natriuretic peptides. Natriuretic peptides are responsible for regulating blood pressure and water balance. Valsartan is an angiotensin receptor blocker (ARB) that works by blocking the effects of angiotensin II. Angiotensin II is responsible for vasoconstriction, which increases blood pressure and reduces blood flow.

Storage Conditions:
Entresto tablets should be stored at room temperature between 15°C to 30°C. The medication should be protected from moisture and light.

Precautions:
Patients should inform their healthcare provider of any allergies or medical conditions before taking Entresto. The medication should not be taken by patients who have a history of angioedema, severe liver disease, or who are pregnant. Patients with renal impairment and low blood pressure should also take precautions. Entresto may interact with other medications, such as diuretics, potassium supplements, and NSAIDs.

Interactions:
Entresto may interact with other medications, such as diuretics, potassium supplements, and NSAIDs. It should not be taken with ACE inhibitors or aliskiren. Patients should inform their healthcare provider of any other medications they are taking, including over-the-counter medications, vitamins, and herbal supplements.

Contraindications:
Entresto should not be taken by patients who have a history of angioedema, severe liver disease, or who are pregnant. The medication should not be taken with ACE inhibitors or aliskiren. Patients with a hypersensitivity to any component of Entresto should avoid taking this medication.

Side effects:
Common side effects of Entresto include dizziness, hypotension, hyperkalemia, cough, and fatigue. Less common side effects may include renal impairment, angioedema, and allergic reactions.

Overdose:
The symptoms of Entresto overdose may include hypotension, elevated creatinine levels, and hyponatremia. In case of overdose, patients should seek medical attention immediately.

In conclusion, Entresto is a combination medication used to treat heart failure with reduced ejection fraction. It should be taken orally with or without food. The dosage may vary based on the patient’s condition and response to the medication. Precautions, contraindications, side effects, and interactions are necessary to consider. Proper storage at room temperature is necessary.