Description: Estram is a medication that contains the active ingredient estramustine phosphate. It is a unique compound that combines features of both a hormone (estrogen) and a chemotherapy agent. Estramustine is primarily used in the treatment of advanced prostate cancer.

Indications:

• Prostate Cancer Treatment: Estramustine is indicated for the treatment of metastatic (advanced) prostate cancer that has not responded to other hormonal or radiation therapies.

Mechanism of Action:

• Estramustine is a combination of estradiol (an estrogen) and a nitrogen mustard derivative. The estrogen component is thought to compete with androgens (male hormones) for binding to prostate cancer cells, inhibiting their growth.
• The nitrogen mustard component acts as a chemotherapy agent, damaging the DNA of cancer cells and preventing their further division.

Administration:

• Estramustine is taken orally in the form of capsules.
• It is usually taken several times a day, and the dosage is determined by the treating healthcare professional.

Monitoring:

• Regular medical check-ups and blood tests are often required during treatment to monitor the patient’s response to the medication and assess for any potential side effects.

Side Effects:

• Common side effects may include nausea, vomiting, diarrhea, breast tenderness or enlargement (gynecomastia), and fluid retention.
• Estramustine may also affect liver function, so regular monitoring of liver enzymes is important.

Precautions:

• Estramustine should not be used in women, especially during pregnancy, as it may cause harm to a developing fetus.
• Patients with a history of cardiovascular disease or blood clotting disorders may require careful monitoring.

Consultation with Healthcare Professional:

• The use of Estram (estramustine) should be discussed thoroughly with a healthcare professional.
• Patients should inform their healthcare provider about their medical history, other medications, and any existing health conditions before starting treatment.

Estramustine is typically reserved for specific situations in the management of advanced prostate cancer when other treatments have not been effective. Its use involves careful consideration of potential side effects and close monitoring to ensure optimal outcomes for the patient. The decision to prescribe Estramustine is based on a thorough evaluation of the patient’s overall health and the specific characteristics of their cancer.