Description:

1. Classification: Letrozole belongs to a class of drugs known as aromatase inhibitors. It is primarily used in the treatment of hormone receptor-positive breast cancer in postmenopausal women.
2. Medical Uses:
   • Breast Cancer Treatment: Letrozole is commonly prescribed as adjuvant therapy for hormone receptor-positive breast cancer in postmenopausal women. It is also used in the treatment of advanced breast cancer.
   • Fertility Treatment: In some cases, Letrozole may be used off-label to induce ovulation in women who are struggling with infertility due to anovulation.
3. Mode of Action:
   • Letrozole works by inhibiting the enzyme aromatase, which is involved in the conversion of androgens to estrogens in peripheral tissues. By reducing estrogen levels, Letrozole helps slow down or inhibit the growth of hormone receptor-positive breast cancer cells.
4. Dosage and Administration:
   • The dosage of Letrozole is determined by a healthcare professional based on the individual’s medical history and response to treatment. It is typically taken orally in the form of tablets, usually once daily.
   • For fertility treatment, Letrozole may be prescribed at a different dosage regimen, and its use should be closely monitored by a fertility specialist.
5. Side Effects:
   • Common side effects of Letrozole may include hot flashes, joint pain, fatigue, nausea, and mood changes. It can also lead to bone thinning (osteoporosis) over time.
   • Rare but serious side effects may include an increased risk of fractures, cardiovascular events, and potential effects on cholesterol levels.
6. Precautions:
   • Before using Letrozole, individuals should inform their healthcare provider about their medical history, including any liver or kidney problems, osteoporosis, or heart disease. It’s important to disclose all medications being taken to avoid potential interactions.
7. Duration of Treatment:
   • The duration of treatment with Letrozole varies depending on the individual’s response to therapy and the stage of breast cancer being treated. It may be used as adjuvant therapy for several years in some cases.
8. Prescription Required:
   • Yes, Letrozole is a prescription medication, and it should only be used under the guidance and supervision of a qualified healthcare professional.
9. Note:
   • Letrozole has been shown to be an effective treatment option for hormone receptor-positive breast cancer in postmenopausal women. However, like all medications, it can have side effects, and its use requires careful monitoring by healthcare professionals.

Individuals should consult their healthcare provider for personalized advice regarding the use of Letrozole, especially regarding dosage, potential side effects, and interactions with other medications or medical conditions.