Description: KLOMEN is a pharmaceutical product manufactured by Kocak Farma. It contains Clomiphene Citrate as its active substance. KLOMEN is available in the form of tablets, with each tablet containing 50 mg of Clomiphene Citrate. It is primarily used in the treatment of ovulatory dysfunction in women and is also sometimes used off-label in men for certain medical conditions.

Active Substance: Clomiphene Citrate is a selective estrogen receptor modulator (SERM) that acts by blocking the negative feedback of estrogen on the hypothalamic-pituitary-ovarian axis. This results in increased secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which stimulate ovulation in women.

Manufacturer: KLOMEN is manufactured by Kocak Farma, a pharmaceutical company known for producing high-quality medications. Kocak Farma adheres to strict manufacturing standards to ensure the safety, efficacy, and consistency of its products.

Usage and Dosage: The dosage and administration of KLOMEN should be determined by a qualified healthcare professional based on individual factors such as the patient’s medical history, response to treatment, and desired outcome. In women, the usual starting dose of Clomiphene Citrate is 50 mg daily for 5 days, starting on the fifth day of the menstrual cycle. Dosage adjustments may be necessary based on ovulatory response.

Storage Conditions: KLOMEN tablets should be stored according to the manufacturer’s instructions, typically in a cool, dry place, away from direct sunlight, and at room temperature. They should be kept out of reach of children and pets.

Mechanism of Action: Clomiphene Citrate works by binding to estrogen receptors in the hypothalamus, blocking the negative feedback of estrogen on the secretion of gonadotropin-releasing hormone (GnRH). This leads to increased secretion of FSH and LH, which stimulate the growth and maturation of ovarian follicles, ultimately leading to ovulation.

Contraindications: KLOMEN is contraindicated in individuals with a known hypersensitivity to Clomiphene Citrate or any components of the formulation. It should not be used in patients with liver disease, ovarian cysts, or abnormal uterine bleeding. Caution should be exercised when prescribing KLOMEN to patients with a history of thromboembolic disorders or visual disturbances.

Adverse Reactions: Common adverse reactions associated with KLOMEN use may include hot flashes, ovarian enlargement, abdominal discomfort, nausea, and headache. More serious adverse effects, such as ovarian hyperstimulation syndrome (OHSS), multiple pregnancies, and visual disturbances, may occur with prolonged or high-dose use. Patients should be monitored closely for signs of ovarian hyperstimulation and other adverse effects, and medical attention should be sought if any concerning symptoms arise.