Overview

Levotiron 25mcg is a pharmaceutical product containing Levothyroxine Sodium as its active ingredient. Levothyroxine Sodium is a synthetic form of the thyroid hormone thyroxine (T4), which is naturally produced by the thyroid gland. It is primarily used in the treatment of hypothyroidism, a condition characterized by an underactive thyroid gland that fails to produce sufficient levels of thyroid hormones. Levotiron helps to restore normal levels of thyroid hormones in the body, thereby alleviating the symptoms associated with hypothyroidism.

Manufactured by Abdi İbrahim, a reputable pharmaceutical company known for its high-quality products, Levotiron 25mcg is available in tablet form, with each tablet containing 25 micrograms of Levothyroxine Sodium. The tablets are packaged in a blister pack containing 50 pills, making it a convenient option for long-term management of thyroid hormone deficiency.

Composition and Ingredients

Each Levotiron 25mcg tablet contains:

• Active Ingredient: Levothyroxine Sodium – 25 micrograms
• Inactive Ingredients: The tablet may also contain excipients such as microcrystalline cellulose, lactose monohydrate, sodium starch glycolate, magnesium stearate, and other components that aid in the stability, bioavailability, and shelf life of the product.

These excipients are generally considered safe and are used in pharmaceutical formulations to ensure the integrity and effectiveness of the active ingredient.

Indications

Levotiron 25mcg is indicated for:

1. Primary Hypothyroidism: Levotiron is commonly prescribed for individuals with primary hypothyroidism, where the thyroid gland is unable to produce adequate amounts of thyroid hormones. This condition may arise due to various causes, including autoimmune diseases (such as Hashimoto’s thyroiditis), surgical removal of the thyroid gland, or exposure to radiation therapy.
2. Secondary Hypothyroidism: In cases where the pituitary gland fails to stimulate the thyroid gland due to a deficiency in thyroid-stimulating hormone (TSH), Levotiron can be used to supplement the body’s thyroid hormone levels.
3. Congenital Hypothyroidism: Newborns and infants with congenital hypothyroidism, a condition present from birth, can be treated with Levotiron to ensure normal growth and development.
4. Subclinical Hypothyroidism: In patients with mild hypothyroidism, characterized by elevated TSH levels but normal T4 levels, Levotiron may be prescribed to prevent progression to overt hypothyroidism and to alleviate symptoms.
5. Thyroid Hormone Replacement Therapy: Levotiron is also used as a replacement therapy in patients who have undergone thyroidectomy (surgical removal of the thyroid gland) or in those with thyroid cancer, where maintaining normal thyroid hormone levels is essential for overall health.

Mechanism of Action

Levothyroxine Sodium, the active ingredient in Levotiron 25mcg, functions as a replacement for the natural thyroid hormone thyroxine (T4). Once administered, Levothyroxine is absorbed into the bloodstream and undergoes conversion to triiodothyronine (T3), the more active form of thyroid hormone. T3 interacts with nuclear receptors in various tissues, influencing the expression of specific genes that regulate metabolism, growth, and development.

By restoring normal thyroid hormone levels, Levotiron helps to:

• Regulate Metabolism: Thyroid hormones play a crucial role in regulating the body’s metabolic rate, influencing how efficiently the body converts food into energy. Levotiron helps to normalize metabolism, reducing symptoms like fatigue, weight gain, and cold intolerance.
• Promote Growth and Development: In children and infants, adequate thyroid hormone levels are essential for normal growth and brain development. Levotiron ensures that growth milestones are met and cognitive function is supported.
• Maintain Cardiovascular Health: Thyroid hormones influence heart rate, cardiac output, and vascular resistance. By normalizing thyroid hormone levels, Levotiron helps to maintain cardiovascular health and reduce the risk of related complications.
• Support Neurological Function: Thyroid hormones are involved in the development and function of the central nervous system. Levotiron helps to alleviate symptoms of hypothyroidism such as depression, memory impairment, and concentration difficulties.
• Regulate Cholesterol Levels: Hypothyroidism is often associated with elevated cholesterol levels. By restoring normal thyroid function, Levotiron can help to lower cholesterol levels and reduce the risk of cardiovascular disease.

Dosage and Administration

General Guidelines:

• Initial Dose: The initial dose of Levotiron 25mcg is typically low, especially in elderly patients or those with cardiovascular disease. The dose may be gradually increased based on the patient’s response and laboratory tests.
• Maintenance Dose: The maintenance dose varies depending on the individual’s thyroid hormone requirements, as determined by regular monitoring of TSH and T4 levels. For most adults, the typical maintenance dose ranges from 25 to 100 micrograms per day.
• Administration: Levotiron should be taken orally, preferably on an empty stomach, 30 minutes to an hour before breakfast. This timing helps to maximize absorption and efficacy. It is recommended to take the tablet with a full glass of water.
• Missed Dose: If a dose is missed, it should be taken as soon as possible, unless it is close to the time of the next dose. Patients should not take two doses at the same time to make up for a missed dose.

Side Effects

While Levotiron 25mcg is generally well-tolerated, some patients may experience side effects, particularly if the dosage is not properly adjusted. Common side effects include:

• Cardiovascular Effects: Palpitations, increased heart rate (tachycardia), and elevated blood pressure may occur, particularly if the dose is too high.
• Gastrointestinal Symptoms: Some patients may experience nausea, vomiting, diarrhea, or abdominal cramps.
• Neurological Effects: Anxiety, nervousness, insomnia, and tremors may occur, especially if the dosage exceeds the patient’s requirements.
• Allergic Reactions: Although rare, some patients may develop an allergic reaction to Levothyroxine or one of the inactive ingredients in the tablet. Symptoms may include rash, itching, swelling, severe dizziness, or difficulty breathing.

Patients experiencing severe side effects or signs of overdose, such as chest pain, rapid heartbeat, or seizures, should seek immediate medical attention.

Contraindications and Precautions

Levotiron 25mcg is contraindicated in certain conditions, and caution should be exercised in others:

• Contraindications:
  • Untreated Adrenal Insufficiency: Levothyroxine can precipitate an adrenal crisis in patients with untreated adrenal insufficiency.
  • Hyperthyroidism: Patients with hyperthyroidism or thyrotoxicosis should not use Levotiron unless specifically prescribed by a healthcare provider.
• Precautions:
  • Cardiovascular Disease: Patients with cardiovascular conditions such as ischemic heart disease or arrhythmias should start with a low dose and be closely monitored.
  • Diabetes: Levothyroxine can affect blood glucose levels. Diabetic patients may require adjustments to their diabetes medication.
  • Bone Density: Long-term use of Levotiron at high doses may reduce bone mineral density, increasing the risk of osteoporosis. Monitoring and dose adjustment are recommended.

Drug Interactions

Levotiron 25mcg may interact with various medications, potentially altering their effects or the efficacy of Levothyroxine:

• Cholestyramine and Colestipol: These medications can reduce the absorption of Levothyroxine. They should be taken at least 4 to 5 hours apart.
• Calcium and Iron Supplements: Calcium carbonate and ferrous sulfate can interfere with the absorption of Levothyroxine. Patients should space out the administration of these supplements and Levotiron.
• Warfarin: Levothyroxine can enhance the effects of anticoagulants like warfarin, increasing the risk of bleeding. Regular monitoring of INR levels is advised.
• Antiepileptic Drugs: Medications such as phenytoin and carbamazepine may increase the metabolism of Levothyroxine, necessitating a dose adjustment.
• Beta-blockers and Digoxin: Levothyroxine may reduce the effectiveness of beta-blockers and digoxin, medications commonly used in cardiovascular diseases.

Patients should inform their healthcare provider of all medications they are taking to avoid potential drug interactions.

Storage and Handling

Levotiron 25mcg tablets should be stored at room temperature, away from direct sunlight, heat, and moisture. The tablets should be kept in their original blister packaging until use to protect them from environmental factors that could degrade the active ingredient. The product should be kept out of reach of children.

Conclusion

Levotiron 25mcg is a reliable and effective treatment for various forms of hypothyroidism. By supplementing the body with Levothyroxine Sodium, it helps to restore normal thyroid hormone levels, alleviating the wide range of symptoms associated with thyroid hormone deficiency. Manufactured by Abdi İbrahim, Levotiron is trusted for its quality and efficacy in the management of thyroid-related conditions.

Patients should use this medication under the guidance of a healthcare provider, with regular monitoring to ensure the correct dosage and to avoid potential side effects or interactions. Proper adherence to the prescribed regimen and regular follow-up appointments are essential to achieving the best therapeutic outcomes with Levotiron 25mcg.