Chemical name: (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid
Formula: C15H12I3NO4
Anabolic activity index: not a steroid
Androgenic activity index: not a steroid

LIOTHYRONINE SODIUM 25mcg – HILMA BIOCARE

Overview: Liothyronine Sodium 25mcg is a medication manufactured by Hilma Biocare containing the active substance Liothyronine Sodium. It is a synthetic form of the thyroid hormone triiodothyronine (T3) and is primarily used in the treatment of hypothyroidism, a condition characterized by insufficient thyroid hormone production. Liothyronine Sodium is also used off-label in the management of certain thyroid disorders and as an adjunct therapy in the treatment of obesity.

Active Substance:

• Liothyronine Sodium: Liothyronine Sodium is a synthetic form of triiodothyronine (T3), which is one of the thyroid hormones produced by the thyroid gland. It plays a crucial role in regulating metabolism, growth, and energy expenditure in the body. Liothyronine Sodium is chemically identical to the naturally occurring T3 hormone and acts by increasing cellular metabolism and energy production.

Indications: Liothyronine Sodium 25mcg is primarily indicated for:

1. Hypothyroidism: It is used in the treatment of hypothyroidism, a condition characterized by low thyroid hormone levels. Liothyronine Sodium helps restore thyroid hormone levels to normal, alleviating symptoms such as fatigue, weight gain, cold intolerance, and depression.
2. Thyroid Disorders: Liothyronine Sodium may be used off-label in the management of certain thyroid disorders, such as thyroid nodules, goiter, or thyroid hormone resistance syndromes.
3. Obesity: Liothyronine Sodium is sometimes used as an adjunct therapy in the treatment of obesity, particularly in individuals with hypothyroidism who have difficulty losing weight despite appropriate diet and exercise.

Mechanism of Action: Liothyronine Sodium exerts its therapeutic effects by binding to thyroid hormone receptors in target tissues throughout the body. As a synthetic form of triiodothyronine (T3), Liothyronine Sodium mimics the actions of endogenous T3 hormone, stimulating cellular metabolism and energy production. This leads to increased basal metabolic rate, enhanced utilization of carbohydrates and fats, and greater heat production (thermogenesis).

Dosage and Administration: The dosage of Liothyronine Sodium 25mcg is individualized based on the patient’s age, weight, thyroid function tests, and response to treatment. It is typically administered orally as a tablet, with dosing frequency adjusted to achieve and maintain euthyroid (normal thyroid function) state. The usual starting dose for adult patients with hypothyroidism is 25mcg per day, with gradual titration based on clinical response and thyroid function tests. Dosage adjustments may be necessary over time to maintain optimal thyroid hormone levels.

Potential Side Effects: Common side effects associated with Liothyronine Sodium may include:

• Palpitations or rapid heart rate
• Sweating or heat intolerance
• Tremors or jitteriness
• Weight loss or appetite changes
• Insomnia or difficulty sleeping
• Diarrhea or gastrointestinal disturbances
• Headache or dizziness

Precautions:

• Liothyronine Sodium should be used with caution in patients with cardiovascular disease, including those with a history of heart attack, angina, or arrhythmias.
• It should be used cautiously in elderly patients and those with adrenal insufficiency or diabetes mellitus.
• Concomitant use of Liothyronine Sodium with certain medications, such as sympathomimetic agents or thyroid hormone replacement therapies, may potentiate adverse effects and require dosage adjustments.
• Patients should be monitored regularly for thyroid function tests, especially during dose titration or changes in medication regimen.

In conclusion, Liothyronine Sodium 25mcg contains the active substance Liothyronine Sodium, a synthetic form of triiodothyronine (T3) used in the treatment of hypothyroidism and certain thyroid disorders. While effective in restoring thyroid hormone levels and alleviating symptoms of hypothyroidism, Liothyronine Sodium may cause side effects and should be used cautiously under medical supervision.