Description:

Merional is a pharmaceutical product containing the active substance human menopausal gonadotropin (hMG). It is commonly used in assisted reproductive technologies (ART) for the treatment of infertility in both men and women. Human menopausal gonadotropin is a purified preparation derived from the urine of postmenopausal women and contains a combination of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which play key roles in the regulation of reproductive function.

Key Points:

• Active Ingredient:
  • Human Menopausal Gonadotropin (hMG): A purified preparation containing FSH and LH extracted from the urine of postmenopausal women. It stimulates ovarian follicle development in women and spermatogenesis in men.
• Indications:
  • Merional is indicated for the treatment of infertility in both men and women. In women, it is used to induce ovulation in cases of anovulatory infertility or to stimulate multiple follicle development in controlled ovarian stimulation (COS) protocols for assisted reproductive technologies (ART) such as in vitro fertilization (IVF). In men, it may be used to stimulate spermatogenesis in cases of hypogonadotropic hypogonadism.
• Mechanism of Action:
  • Human menopausal gonadotropin acts on the ovaries in women and the testes in men to stimulate the production and maturation of follicles and sperm, respectively. FSH promotes the growth and maturation of ovarian follicles in women, while LH stimulates ovulation and the production of testosterone in men.
• Dosage Form:
  • Merional is available as a sterile lyophilized powder for injection, typically supplied in ampules containing a specific number of International Units (IU) of FSH and LH.
• Dosage and Administration:
  • The dosage of Merional is individualized based on factors such as the patient’s age, weight, ovarian reserve, and response to previous treatments. It is usually administered by subcutaneous or intramuscular injection, with the timing and duration of treatment determined by the specific fertility protocol being used.
• Precautions:
  • Merional should be used with caution in patients with a history of ovarian hyperstimulation syndrome (OHSS), ovarian cysts, or hormone-sensitive tumors. Close monitoring of ovarian response and hormone levels is essential to minimize the risk of complications.
• Possible Side Effects:
  • Common side effects of Merional may include injection site reactions, ovarian enlargement, abdominal discomfort, and hormonal fluctuations. Rare but serious side effects such as ovarian torsion, OHSS, and allergic reactions may occur.
• Manufacturer:
  • Merional is manufactured by IBSA, a pharmaceutical company known for its expertise in reproductive medicine and hormone therapies.

Note: Merional is a valuable treatment option for couples struggling with infertility, offering a safe and effective way to stimulate ovulation and improve fertility outcomes. Patients undergoing fertility treatments with Merional should receive comprehensive counseling and support from fertility specialists to maximize the chances of success and minimize the risks associated with treatment. Regular monitoring and adjustment of treatment protocols based on individual responses are essential for optimizing fertility treatment outcomes.