Nexletol (bempedoic acid) is a medication used to manage cholesterol levels in individuals with hypercholesterolemia by blocking the production of cholesterol in the liver. This medication is produced by Esperion Therapeutics and is available in tablet form.

Uses:
Nexletol is mainly used to lower LDL cholesterol levels. It is used as an adjunct to maximally tolerated statin therapy in individuals with primary hypercholesterolemia.

HOW TO USE:
Nexletol should be taken orally with or without food. The tablets should be swallowed whole and should not be crushed, chewed, or broken. The dosage and duration of the medication may vary based on the patient’s condition and response to the medication.

Dosage:
The recommended dose of Nexletol is 180 mg once daily. This medication can be taken with or without food. Treatment with Nexletol should be monitored and may be adjusted based on the patient’s response and concern for adverse effects.

Mechanism of action:
Nexletol works by inhibiting ATP citrate lyase, an important enzyme that is involved in the production of cholesterol. By inhibiting this enzyme, Nexletol reduces the production of cholesterol in the liver, which leads to a decrease in LDL cholesterol levels.

Storage Conditions:
Nexletol tablets should be stored at room temperature between 20°C to 25°C. This medication should be protected from moisture and light.

Precautions:
Patients should inform their healthcare provider of any allergies or medical conditions before taking Nexletol. The medication should not be taken by patients with severe hepatic impairment or who are pregnant or breastfeeding. Patients with renal impairment and moderate hepatic impairment should also take precautions. Nexletol may interact with other medications, such as statins, cyclosporine, and fibrates.

Interactions:
Nexletol may interact with other medications, such as statins, cyclosporine, and fibrates. Patients should inform their healthcare provider of any other medications they are taking, including over-the-counter medications, vitamins, and herbal supplements.

Contraindications:
Nexletol should not be taken by patients with a hypersensitivity to any component of the medication, active liver disease, or who are pregnant or breastfeeding.

Side effects:
Common side effects of Nexletol include diarrhea, muscle spasms, back pain, joint pain, and constipation. Less common side effects may include anemia, gout and tendonitis.

Overdose:
Currently, there is limited information on the specific symptoms that may occur with Nexletol overdose. In case of overdose, patients should seek medical attention immediately.

In conclusion, Nexletol is a medication used to manage cholesterol levels in individuals with hypercholesterolemia. It should be taken orally with or without food, and the dosage and duration may vary based on the patient’s condition and response. Precautions, contraindications, side effects, and interactions are necessary to consider. Proper storage is required at room temperature.