Orladeyo (berotralstat) is a medication used to treat hereditary angioedema (HAE) in adults. It is produced by BioCryst Pharmaceuticals and is available in capsule form.

Uses:
Orladeyo is mainly used to prevent and reduce the frequency of attacks in individuals with HAE. It blocks the activity of plasma kallikrein, an enzyme that plays a role in the production of bradykinin, a substance that causes swelling and inflammation.

HOW TO USE:
Orladeyo should be taken orally with food to help increase its absorption. The capsules should be swallowed whole and should not be crushed, chewed, or broken. The treatment with Orladeyo may be monitored and adjusted based on the patient’s response and concern for side effects.

Dosage:
The recommended dose of Orladeyo is 150 mg capsule taken once daily. Treatment with Orladeyo should be initiated under the supervision of a healthcare provider experienced in the management of HAE.

Mechanism of action:
Orladeyo works by targeting plasma kalikrein, an enzyme that contributes to the production of bradykinin, a substance that causes swelling and inflammation. By inhibiting plasma kalikrein, Orladeyo reduces the production of bradykinin, which leads to a decrease in the frequency and severity of HAE attacks.

Storage Conditions:
Orladeyo capsules should be stored at room temperature between 20°C to 25°C. This medication should be protected from moisture and should be kept in its original container.

Precautions:
Patients should inform their healthcare provider if they have any allergies or medical conditions before taking Orladeyo. Patients should also inform their healthcare provider of other medications they are taking, including over-the-counter medications, vitamins, and herbal supplements.

Interactions:
Orladeyo may interact with other medications that affect the cytochrome P450 system, such as clarithromycin. Patients should inform their healthcare provider of any other medications they are taking to avoid potential interactions.

Contraindications:
Orladeyo should not be taken by patients with a hypersensitivity to any component of the medication. This medication is not recommended for use during pregnancy or breastfeeding.

Side effects:
Common side effects of Orladeyo include abdominal pain, nausea, vomiting, and diarrhea. Less common side effects may include headache, fatigue, and dizziness.

Overdose:
Currently, there is limited information on the specific symptoms that may occur with an Orladeyo overdose. In case of an overdose, patients should seek medical attention immediately.

In conclusion, Orladeyo is a medication used to prevent and reduce the frequency of HAE attacks. It is taken orally with food and should not be crushed, chewed, or broken. The recommended dosage is a 150 mg capsule taken once daily. Precautions, interactions, contraindications, and side effects, including abdominal pain, nausea, and vomiting, should be considered. Proper storage conditions should be maintained at room temperature.