Description: Orliford-120 is a medication manufactured by Banford. It contains the active substance orlistat. Each package contains 10 pills, with each pill containing 120 milligrams of orlistat. Orliford-120 is primarily used as a weight loss aid in combination with a reduced-calorie diet and exercise program. It works by blocking the absorption of dietary fat in the intestines, thereby reducing calorie intake and promoting weight loss.

Active Substance: The active substance in Orliford-120 is orlistat. Orlistat is a lipase inhibitor that works by inhibiting the action of pancreatic lipase, an enzyme responsible for breaking down dietary fats into smaller molecules that can be absorbed by the body. By blocking the activity of pancreatic lipase, orlistat reduces the absorption of dietary fats, leading to decreased caloric intake and weight loss.

Indications: Orliford-120 is indicated for the treatment of obesity in adults and adolescents aged 12 years and older. It is used as an adjunct to a reduced-calorie diet and exercise program to help individuals achieve and maintain weight loss.

Mechanism of Action:

• Orlistat works locally in the gastrointestinal tract, where it inhibits the action of pancreatic lipase, the enzyme responsible for breaking down dietary fats into absorbable fatty acids and monoglycerides.
• By blocking pancreatic lipase activity, orlistat prevents the hydrolysis of dietary fats, leading to the excretion of undigested fat in the stool.
• This reduces the amount of fat absorbed by the body, resulting in a decrease in calorie intake and promoting weight loss.

Administration:

• Orliford-120 capsules are taken orally with water, usually three times daily during or up to 1 hour after each main meal that contains fat.
• The capsules should be swallowed whole and should not be chewed, crushed, or opened.
• It is important to adhere to a reduced-calorie diet containing no more than 30% of calories from fat while taking orlistat to optimize weight loss results.

Dosage:

• The recommended dosage of Orliford-120 is one 120-milligram capsule taken three times daily, with each main meal that contains fat.
• The total daily dose should not exceed 360 milligrams per day.
• If a meal is missed or contains no fat, the dose of orlistat can be omitted.

Monitoring:

• Patients taking Orliford-120 should be monitored for any signs of adverse effects, including gastrointestinal symptoms such as oily spotting, fecal urgency, or fatty/oily stools.
• Regular monitoring of weight loss progress, dietary adherence, and potential nutritional deficiencies may also be necessary.

Side Effects: Common side effects of orlistat may include:

• Gastrointestinal symptoms such as oily spotting, fecal urgency, or fatty/oily stools
• Abdominal pain or discomfort
• Flatulence (gas)
• Increased frequency of bowel movements
• Headache
• Back pain

Precautions:

• Orliford-120 should be used with caution in patients with a history of gastrointestinal disorders, including malabsorption syndromes or cholestasis.
• It is contraindicated in patients with chronic malabsorption syndrome or cholestasis, as orlistat may exacerbate these conditions.
• Patients should be advised to take a multivitamin supplement containing fat-soluble vitamins (such as vitamins A, D, E, and K) at least 2 hours before or after taking orlistat to prevent potential deficiencies.

Consultation with Healthcare Professional:

• The use of Orliford-120 should be discussed with a healthcare professional, particularly for individuals with underlying health conditions or those taking other medications.
• Patients should inform their healthcare provider about their medical history, existing health conditions, and any medications they are taking before starting treatment with orlistat.

Orliford-120, manufactured by Banford, is a medication indicated for the treatment of obesity in adults and adolescents aged 12 years and older. Its use involves careful adherence to dosage and instructions for use, as well as compliance with a reduced-calorie diet and exercise program, to optimize weight loss results.