Oxlumo (lumasiran) is a prescription medication used to treat primary hyperoxaluria type 1 (PH1), a rare genetic disorder that causes the body to produce too much oxalate. Oxalate is a chemical that can form crystals in the kidneys, bladder, and other organs, leading to serious health problems.
Description
Oxlumo is a small interfering RNA (siRNA) that blocks the production of glycolate oxidase, an enzyme that is involved in the production of oxalate. By blocking glycolate oxidase production, Oxlumo helps to reduce oxalate levels in the body.
Uses
Oxlumo is used to treat adults with PH1 who are at risk of developing serious complications from oxalate overload, such as kidney failure, bladder stones, and cardiovascular disease.
How to Use
Oxlumo is administered as a subcutaneous injection by a healthcare professional. The recommended dosage is 300 milligrams (mg) every 3 months.
Dosage
The recommended dosage of Oxlumo is 300 mg administered as a single subcutaneous injection every 3 months.
Mechanism of Action
Oxlumo is a small interfering RNA (siRNA) that blocks the production of glycolate oxidase, an enzyme that is involved in the production of oxalate. By blocking glycolate oxidase production, Oxlumo helps to reduce oxalate levels in the body.
Storage Conditions
Oxlumo should be stored in the refrigerator (2-8°C or 36-46°F) in the original carton to protect from light. Do not freeze.
Precautions
- Oxlumo should not be used in people who are allergic to lumasiran or any of the other ingredients in Oxlumo.
- Oxlumo should be used with caution in people with liver disease or kidney disease.
- Oxlumo should not be used in pregnant or breastfeeding women.
Interactions
Oxlumo may interact with other medications, including blood thinners, corticosteroids, and diuretics. It is important to tell your healthcare provider about all of the medications you are taking before starting Oxlumo.
Contraindications
Oxlumo is contraindicated in people who are allergic to lumasiran or any of the other ingredients in Oxlumo.
Side Effects
The most common side effects of Oxlumo are:
- Injection site reactions (pain, redness, swelling)
- Fatigue
- Headache
- Nausea
- Diarrhea
Overdose
There is no information on the overdose of Oxlumo. However, if you think you have overdosed on Oxlumo, contact your healthcare provider or poison control center immediately.
Please note that this is not a complete list of all the information you need to know about Oxlumo. Be sure to talk to your healthcare provider for more information and to see if Oxlumo is right for you.
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