Regorafenib: Regorafenib is a tyrosine kinase inhibitor used in the treatment of certain cancers. It belongs to a class of drugs that target specific enzymes involved in the growth and spread of cancer cells.

Mechanism of Action: Regorafenib inhibits multiple kinases involved in angiogenesis (formation of new blood vessels) and tumor growth. It acts by blocking the activity of receptors such as vascular endothelial growth factor receptors (VEGFR), platelet-derived growth factor receptors (PDGFR), and others.

Indications: Regorafenib is indicated for the treatment of:

• Metastatic colorectal cancer (CRC) that has progressed after treatment with standard therapies.
• Advanced gastrointestinal stromal tumors (GIST) that have not responded to other treatments.
• Hepatocellular carcinoma (HCC) in patients who have been previously treated with sorafenib.

Dosage: The dosage of Regorafenib is determined by the healthcare provider based on the specific type of cancer being treated, the patient’s overall health, and other factors. It is typically taken orally in the form of tablets.

Administration: Regorafenib tablets are usually taken once daily with a low-fat meal, as directed by the healthcare provider.

Side Effects: Common side effects of Regorafenib may include fatigue, hand-foot skin reaction, diarrhea, hypertension, and loss of appetite. Serious side effects can include liver problems, bleeding, and gastrointestinal perforation.

Precautions: Regorafenib should be used with caution in patients with a history of certain medical conditions, and regular monitoring of blood pressure, liver function, and other parameters is typically conducted during treatment.

Interactions: Regorafenib may interact with certain medications, and patients should inform their healthcare provider of all medications, supplements, and herbal products they are taking.

Monitoring: Regular monitoring by a healthcare provider is essential to assess the effectiveness of the treatment, manage side effects, and watch for any complications.

If “Resihance” is a specific brand name or formulation, I recommend checking with healthcare providers or updated medical sources for the most current and accurate information.