Rezurock (belumosudil) is a prescription medicine that belongs to the drug class of kinase inhibitors. It is used to treat adults and children 12 years of age and older with chronic graft-versus-host disease (chronic GVHD) after failure of at least two prior lines of systemic therapy.

Mechanism of Action

Rezurock works by blocking the activity of a protein called Rho-associated coiled-coil containing protein kinase 2 (ROCK2). ROCK2 is involved in inflammation and fibrosis, which are two of the main features of chronic GVHD. By blocking ROCK2, Rezurock can help to reduce inflammation and fibrosis, and improve symptoms of chronic GVHD.

Dosage and Administration

Rezurock is taken once a day by mouth. The starting dose is 200 milligrams (mg). The dose may be increased or decreased depending on how well you tolerate the medicine and how well it is working.

Effectiveness

Rezurock has been shown to be effective in improving symptoms of chronic GVHD in clinical trials. In one study, Rezurock led to an improvement in overall response rate (ORR) of 70% in patients with chronic GVHD who had failed at least two prior lines of systemic therapy.

Side Effects

The most common side effects of Rezurock are:

• Low blood counts (white blood cells, red blood cells, and platelets)
• Diarrhea
• Nausea
• Fatigue
• Liver problems
• Kidney problems
• High blood pressure
• High cholesterol
• Low blood sugar
• Decreased appetite
• Muscle pain
• Joint pain
• Headache
• Rash
• Hair loss

Rezurock can also cause serious side effects, such as:

• Severe infections
• Bleeding
• Liver failure
• Kidney failure
• Heart problems
• Lung problems
• Allergic reactions

Contraindications

Rezurock is not safe for everyone. Tell your doctor if you are pregnant or breastfeeding, or if you have any other medical conditions, including:

• Liver disease
• Kidney disease
• Heart disease
• Lung disease
• Low blood counts
• Allergies

Rezurock may also interact with other medications you are taking. Tell your doctor about all the medications you are taking, including prescription drugs, over-the-counter drugs, vitamins, and herbal supplements.

Conclusion

Rezurock is an effective treatment for chronic GVHD in patients who have failed at least two prior lines of systemic therapy. However, it is important to be aware of the potential side effects of Rezurock before starting treatment. Talk to your doctor about the risks and benefits of Rezurock to determine if it is right for you.