Chemical name: 1-((3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine citrate
Formula: C28H38N6O11S
Anabolic activity index: not a steroid
Androgenic activity index: not a steroid
SILDIGRA-100
Description:
SILDIGRA-100, manufactured by RSM Pharma, is a pharmaceutical-grade medication containing the active substance Sildenafil. These tablets are formulated to address erectile dysfunction (ED), a common condition characterized by the inability to achieve or maintain an erection sufficient for satisfactory sexual performance. Sildenafil, the active ingredient in SILDIGRA-100, belongs to a class of medications known as phosphodiesterase type 5 (PDE5) inhibitors, which work by increasing blood flow to the penis during sexual stimulation, thereby facilitating erections.
Indication:
SILDIGRA-100 is indicated for the treatment of erectile dysfunction (ED) in adult men. It is prescribed to improve erectile function and enhance sexual performance by increasing blood flow to the penis during sexual stimulation. Sildenafil is not indicated for use in women or children and should only be used as directed by a healthcare professional.
Mechanism of Action:
Sildenafil exerts its effects by selectively inhibiting the enzyme phosphodiesterase type 5 (PDE5), which is responsible for the degradation of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum of the penis. Inhibition of PDE5 leads to increased levels of cGMP, which in turn promotes relaxation of smooth muscle cells and vasodilation of blood vessels in the penis. This results in improved blood flow to the erectile tissue, leading to the formation and maintenance of erections suitable for sexual activity.
Administration:
SILDIGRA-100 tablets are intended for oral administration and should be swallowed whole with a glass of water. They can be taken with or without food, although consuming a high-fat meal may delay the onset of action. It is essential to follow the prescribed dosage and administration instructions provided by a healthcare professional to achieve optimal therapeutic outcomes.
Dosage:
Each SILDIGRA-100 tablet contains 100 mg of Sildenafil. The recommended dosage for most adult men is one tablet taken orally approximately 30 to 60 minutes before anticipated sexual activity. The onset of action may vary among individuals, but Sildenafil typically reaches peak plasma concentrations within 1 to 2 hours after administration. Dosage adjustments may be necessary based on individual response and tolerability.
Efficacy:
SILDIGRA-100 has demonstrated efficacy in the treatment of erectile dysfunction, with clinical studies showing significant improvements in erectile function, sexual satisfaction, and overall quality of life in men with this condition. Sildenafil has been shown to increase the frequency and duration of erections, as well as to enhance the ability to achieve and maintain erections sufficient for satisfactory sexual intercourse.
Side Effects:
While generally well-tolerated, SILDIGRA-100 may be associated with certain side effects, particularly when used at higher doses or in individuals with underlying health conditions. Common side effects may include headache, flushing, dyspepsia, nasal congestion, and dizziness. Less common but more severe side effects such as priapism (prolonged erection), changes in vision or hearing, and allergic reactions can occur and require medical attention.
Precautions:
Before using SILDIGRA-100, individuals should undergo a thorough medical evaluation to assess their suitability for treatment and to identify any contraindications or risk factors. Sildenafil should not be used in combination with nitrates or nitric oxide donors, as this can lead to severe hypotension. It is essential to inform a healthcare professional about any pre-existing medical conditions, medications, or supplements being taken to avoid potential drug interactions or adverse effects.
In conclusion, SILDIGRA-100 tablets manufactured by RSM Pharma offer a reliable and effective treatment option for erectile dysfunction in adult men. When used as directed under the guidance of a healthcare professional, Sildenafil can help improve erectile function, enhance sexual performance, and restore confidence in sexual relationships. However, it is essential to weigh the benefits against the risks and to prioritize safety and monitoring to minimize potential adverse effects and ensure optimal therapeutic outcomes.
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