Chemical name:(Z)-2-[4-(1,2-Diphenylbut-1-enyl)phenoxy]-N,N-dimethylethanamine
Formula: C26H29NO
Anabolic activity index: not a steroid
Androgenic activity index: not a steroid

TAMOXIFEN CITRATE 20mg – HILMA BIOCARE

Overview: Tamoxifen Citrate is a medication commonly used in the treatment and prevention of certain types of breast cancer. It belongs to a class of drugs known as selective estrogen receptor modulators (SERMs) and is recognized for its antiestrogenic properties.

Active Ingredient:

• Tamoxifen Citrate: This is the citrate salt form of tamoxifen. Tamoxifen acts as an antagonist (blocks) estrogen receptors in breast tissue, inhibiting the growth of estrogen-dependent tumors.

Indications: Tamoxifen Citrate is primarily indicated for:

1. Breast Cancer Treatment: It is used in the treatment of estrogen receptor-positive breast cancer, both in premenopausal and postmenopausal women.
2. Breast Cancer Prevention: Tamoxifen may be prescribed for women at high risk of developing breast cancer to reduce the risk of its occurrence.
3. Adjuvant Therapy: Tamoxifen is often used as adjuvant therapy following surgery, radiation, or chemotherapy to reduce the risk of cancer recurrence.
4. Metastatic Breast Cancer: In cases of advanced or metastatic breast cancer, Tamoxifen may be used to control the spread of the disease.

Mechanism of Action: Tamoxifen works by competitively binding to estrogen receptors on breast cells, preventing estrogen from binding. This action inhibits estrogen’s stimulatory effect on breast cancer cell growth. Tamoxifen is often referred to as an estrogen receptor antagonist in breast tissue.

Dosage and Administration: The dosage and duration of Tamoxifen Citrate treatment are determined by the healthcare provider based on the specific type and stage of breast cancer. It is typically taken orally as a tablet.

Side Effects: Common side effects of Tamoxifen Citrate may include hot flashes, nausea, fatigue, mood swings, and an increased risk of blood clots. Serious side effects such as endometrial cancer and thromboembolic events are possible, but the benefits and risks are carefully considered by healthcare professionals.

Monitoring: Regular monitoring and follow-ups with a healthcare provider are essential during Tamoxifen treatment to assess its effectiveness and manage potential side effects.

Precautions and Considerations:

• Pregnancy and Fertility: Tamoxifen should not be used during pregnancy, and effective contraception is recommended during treatment due to the risk of fetal harm. It may also affect fertility.
• Bone Health: Long-term use of Tamoxifen may have implications for bone health, and calcium and vitamin D supplementation may be advised.
• Interaction with Other Medications: Certain medications, including those affecting liver enzymes, may interact with Tamoxifen, and patients should inform their healthcare provider of all medications being taken.

Prescription Requirement: Tamoxifen Citrate is available only with a prescription and should be taken under the supervision of a qualified healthcare professional.

In summary, Tamoxifen Citrate is a widely used medication in the treatment and prevention of breast cancer. Its mechanism of action as an estrogen receptor modulator has made it a valuable tool in managing estrogen-dependent breast tumors. However, its use involves careful consideration of potential side effects and individual health factors, and it should be administered and monitored by healthcare professionals.