Tarpeyo (budesonide) is a prescription medication that belongs to the drug class of corticosteroids. It is used to treat adults with primary immunoglobulin A nephropathy (IgA nephropathy) at risk of rapid disease progression, generally a urine protein-to-creatinine ratio (UPCR) ≥ 1.5 g/g.

Mechanism of Action

Budesonide works by reducing inflammation and suppressing the immune system. This can help to slow the progression of IgA nephropathy and protect the kidneys from further damage.

Dosage and Administration

Tarpeyo is taken once daily by mouth, in the morning at least 1 hour before a meal. The recommended dosage is 16 mg.

Effectiveness

In clinical trials, Tarpeyo has been shown to be effective in reducing proteinuria in patients with IgA nephropathy. In one study, Tarpeyo reduced proteinuria by 40% or more in 57% of patients after 12 months of treatment.

Side Effects

The most common side effects of Tarpeyo are:

• Headache
• Diarrhea
• Nausea
• Upper respiratory infection
• Nasopharyngitis
• Fatigue
• Back pain
• Arthralgia
• Myalgia
• Rash

Tarpeyo can also cause serious side effects, such as:

• Adrenal insufficiency
• Cushing’s syndrome
• Hyperglycemia
• Hypokalemia
• Hypertension
• Osteoporosis
• Muscle weakness
• Cataracts
• Glaucoma
• Peptic ulcer
• Increased risk of infection

Contraindications

Tarpeyo is not safe for everyone. Tell your doctor if you are pregnant or breastfeeding, or if you have any other medical conditions, including:

• Active tuberculosis
• Systemic fungal infection
• Hypersensitivity to budesonide or any other ingredients in Tarpeyo

Tarpeyo may also interact with other medications you are taking. Tell your doctor about all the medications you are taking, including prescription drugs, over-the-counter drugs, vitamins, and herbal supplements.

Conclusion

Tarpeyo is an effective treatment for IgA nephropathy in adults at risk of rapid disease progression. However, it is important to be aware of the potential side effects of Tarpeyo before starting treatment. Talk to your doctor about the risks and benefits of Tarpeyo to determine if it is right for you.