Description: Tilidin 50x 200/16mg is a medication manufactured by Hexal AG containing the active substance tilidine. Tilidine is an opioid analgesic used primarily for the management of moderate to severe pain. The combination of 200mg tilidine hydrochloride and 16mg of the opioid antagonist naloxone (as 20mg of naloxone hydrochloride dihydrate) is formulated to provide effective pain relief while reducing the risk of opioid abuse and dependence.

Indications:

• Tilidin 50x 200/16mg is indicated for the relief of moderate to severe pain, such as postoperative pain, cancer pain, and other types of chronic pain conditions where opioid analgesia is necessary.

Mechanism of Action:

• Tilidine acts as an agonist at the μ-opioid receptors in the central nervous system, producing analgesia by altering the perception and response to pain stimuli. Naloxone, included in the formulation to deter abuse via injection, acts as a competitive antagonist at opioid receptors, limiting the effects of tilidine when taken by injection.

Administration:

• Tilidin 50x 200/16mg is usually administered orally in the form of tablets. The dosage and frequency of administration should be determined by a healthcare professional based on the severity of pain and individual patient response.

Dosage:

• The typical dosage of Tilidin 50x 200/16mg may vary depending on factors such as the patient’s age, weight, and overall health status. It is essential to follow the prescribed dosage regimen and not to exceed the recommended dose.

Side Effects:

• Common side effects of Tilidin 50x 200/16mg may include dizziness, drowsiness, nausea, vomiting, constipation, and dry mouth. Less common but more severe side effects may include respiratory depression, sedation, and opioid dependence or withdrawal symptoms with prolonged use.

Contraindications and Precautions:

• Tilidin 50x 200/16mg is contraindicated in patients with known hypersensitivity to tilidine, naloxone, or any other ingredients in the formulation. It should be used with caution in patients with respiratory depression, asthma, paralytic ileus, and other conditions affecting the respiratory or gastrointestinal systems.

Drug Interactions:

• Tilidin 50x 200/16mg may interact with other medications, including other opioids, sedatives, tranquilizers, and certain antidepressants, potentially leading to additive central nervous system depression. It is essential to consult a healthcare professional before combining Tilidin with other medications.

Storage:

• Tilidin 50x 200/16mg should be stored at room temperature away from moisture and heat. Keep the medication out of reach of children and pets and dispose of any unused or expired medication properly.

Patient Counseling:

• Patients prescribed Tilidin 50x 200/16mg should be counseled on the proper use of the medication, including dosage instructions, potential side effects, and the importance of avoiding alcohol and other central nervous system depressants while taking the medication.

It’s crucial for patients to follow their healthcare provider’s recommendations regarding the use of Tilidin 50x 200/16mg and to report any adverse effects or concerns promptly.