Chemical name: (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid
Formula: C15H12I3NO4

Description:

Tiromel is a pharmaceutical product containing the active substance liothyronine sodium. It is primarily used for the treatment of hypothyroidism, a condition characterized by an underactive thyroid gland, where the thyroid gland does not produce enough thyroid hormone. Liothyronine sodium is a synthetic form of triiodothyronine (T3), a thyroid hormone essential for regulating metabolism, growth, and energy levels in the body.

Key Points:

• Active Ingredient:
  • Liothyronine Sodium: A synthetic form of triiodothyronine (T3), which is the active thyroid hormone responsible for regulating metabolism, energy production, and various physiological processes in the body.
• Indications:
  • Tiromel is indicated for the treatment of hypothyroidism, a condition characterized by insufficient thyroid hormone production, resulting in symptoms such as fatigue, weight gain, cold intolerance, and sluggishness.
• Mechanism of Action:
  • Liothyronine sodium works by replacing or supplementing the deficient thyroid hormone levels in individuals with hypothyroidism. It acts similarly to endogenous T3, binding to thyroid hormone receptors in target tissues to regulate metabolism and energy production.
• Dosage Form:
  • Tiromel is available as oral tablets, typically supplied in blister packs containing a specific number of pills, each containing 25 mcg of liothyronine sodium.
• Dosage and Administration:
  • The dosage of Tiromel is individualized based on factors such as the patient’s age, weight, thyroid function tests, and response to treatment. It is usually taken orally once daily, preferably in the morning, on an empty stomach, at least 30 minutes before breakfast.
• Monitoring:
  • Patients taking Tiromel require regular monitoring of thyroid function tests, including serum thyroid-stimulating hormone (TSH), free thyroxine (FT4), and free triiodothyronine (FT3) levels, to ensure optimal thyroid hormone replacement and to avoid under- or over-treatment.
• Precautions:
  • Tiromel should be used with caution in patients with cardiovascular disease, adrenal insufficiency, diabetes mellitus, or pituitary disorders. Dosage adjustments may be necessary in these populations to avoid exacerbating underlying medical conditions.
• Possible Side Effects:
  • Common side effects of liothyronine sodium may include palpitations, tachycardia, tremors, insomnia, weight loss, and heat intolerance. Rare but serious side effects such as cardiac arrhythmias, angina, and exacerbation of underlying cardiac conditions may occur.
• Manufacturer:
  • Tiromel is manufactured by Abdi Ibrahim, a reputable pharmaceutical company known for its high-quality medications and commitment to patient care.

Note: Tiromel provides an effective treatment option for individuals with hypothyroidism, helping to alleviate symptoms and improve overall quality of life. Patients should be educated about the proper use of Tiromel, including the importance of adherence to prescribed dosing regimens and regular follow-up appointments with healthcare providers for monitoring and adjustment of treatment as needed. It is essential to discuss the potential risks and benefits of Tiromel therapy with a healthcare provider to ensure safe and effective use.