Chemical name: 2-[4-[(~{Z})-4-chloro-1,2-diphenylbut-1-enyl]phenoxy]-~{N},~{N}-dimethylethanamine;2-hydroxypropane-1,2,3-tricarboxylic acid
C32H36ClNO8
Anabolic activity index: not a steroid
Androgenic activity index: not a steroid

TOREMFINE 20mg – DRAGON PHARMA

Toremifene citrate is a selective estrogen receptor modulator (SERM) that is used primarily in the treatment of certain types of breast cancer. It works by blocking the effects of estrogen in breast tissue. Here is a detailed description of toremifene citrate:

Chemical Composition: Toremifene citrate is the citrate salt form of toremifene, a nonsteroidal triphenylethylene derivative. It is structurally related to tamoxifen, another well-known SERM.

Mechanism of Action: As a SERM, toremifene citrate exerts its effects by binding to estrogen receptors in the body, particularly in breast tissue. By doing so, it competes with estrogen for binding to these receptors, thus modulating estrogenic activity. In breast cancer treatment, this is crucial as certain types of breast cancer cells are stimulated by estrogen. Toremifene’s antiestrogenic effects help inhibit the growth of estrogen-dependent tumors.

Medical Uses: Toremifene citrate is primarily indicated for the treatment of metastatic breast cancer in postmenopausal women with estrogen receptor-positive or unknown receptor status. It may be used as a monotherapy or in conjunction with other treatments.

Adjuvant Therapy: In addition to treating metastatic breast cancer, toremifene citrate is sometimes used as adjuvant therapy, particularly in postmenopausal women with early-stage breast cancer who are at an increased risk of recurrence. It may be considered after surgery or radiation therapy.

Estrogen Receptor-Positive Breast Cancer: Toremifene citrate is particularly effective in estrogen receptor-positive breast cancer, where cancer growth is influenced by estrogen. By blocking estrogen receptors, it helps impede the growth of cancer cells.

Side Effects: Common side effects of toremifene citrate include hot flashes, sweating, nausea, and visual disturbances. In rare cases, it can cause more serious side effects such as blood clots, stroke, or endometrial cancer. The risk-benefit profile is carefully considered by healthcare professionals when prescribing this medication.

Contraindications: Toremifene citrate is contraindicated in individuals with a known hypersensitivity to the drug. It should be used with caution in patients with a history of blood clots, stroke, or other cardiovascular issues.

Monitoring and Precautions: Regular monitoring, including blood tests and eye examinations, may be required during treatment with toremifene citrate. It is essential for healthcare professionals to assess the individual patient’s medical history and overall health before prescribing this medication.

As with any prescription medication, individuals should only use toremifene citrate under the supervision of a qualified healthcare professional. The information provided here is a general overview, and specific details may vary based on the patient’s condition, medical history, and the prescribing physician’s recommendations.