Velpanat is a combination medication containing two active ingredients: Velpatasvir and Sofosbuvir. It is primarily used in the treatment of chronic hepatitis C virus (HCV) infection. Velpatasvir is a pangenotypic NS5A inhibitor, while Sofosbuvir is a nucleotide analog NS5B polymerase inhibitor. Together, they work to inhibit the replication of the hepatitis C virus, ultimately leading to its suppression and clearance from the body. Here is a detailed description of Velpanat (Velpatasvir & Sofosbuvir Tablet 28’s):

1. Mechanism of Action:

• Velpatasvir inhibits the NS5A protein, which is essential for the replication of the hepatitis C virus.
• Sofosbuvir is a prodrug that is metabolized in the body to form an active nucleoside analog triphosphate. This compound acts as a substrate for the NS5B polymerase, leading to chain termination and inhibition of viral RNA synthesis.

2. Indications:

• Velpanat (Velpatasvir & Sofosbuvir) is indicated for the treatment of chronic hepatitis C virus (HCV) infection in adults.
• It is effective against multiple genotypes (1-6) of the hepatitis C virus.

3. Dosage:

• The dosage of Velpanat is determined by the healthcare provider based on factors such as the patient’s genotype, liver function, previous treatment history, and other medical considerations.
• It is typically taken orally in the form of tablets.

4. Administration:

• Velpanat tablets are usually taken once daily with or without food, as directed by the healthcare provider.
• The tablets should be swallowed whole with a glass of water.

5. Potential Side Effects:

• Common side effects of Velpanat may include fatigue, headache, nausea, insomnia, and diarrhea.
• Serious side effects can include liver problems, allergic reactions, and exacerbation of hepatitis B in co-infected individuals.

6. Precautions:

• Velpanat should be used with caution in patients with certain medical conditions, such as severe kidney disease or liver impairment.
• Patients should inform their healthcare provider of any pre-existing conditions or medications they are taking.

7. Interactions:

• Velpanat may interact with certain medications, particularly those that are metabolized by the cytochrome P450 enzyme system.
• Patients should inform their healthcare provider of all medications, supplements, and herbal products they are taking.

8. Monitoring:

• Regular monitoring of liver function and viral load is important to assess the effectiveness of the treatment and watch for any side effects or complications.

Velpanat (Velpatasvir & Sofosbuvir) represents an important therapeutic option for individuals with chronic hepatitis C virus infection. Its use should be under the supervision of a qualified healthcare professional, and patients are advised to follow their healthcare provider’s recommendations closely for optimal safety and efficacy.