Viread is a medication that contains the active ingredient tenofovir disoproxil fumarate. It belongs to a class of drugs known as nucleoside reverse transcriptase inhibitors (NRTIs) and is primarily used in the treatment of human immunodeficiency virus (HIV) infection and chronic hepatitis B virus (HBV) infection. Here is a comprehensive description of Viread (tenofovir disoproxil fumarate) 300 mg tablets:

Mechanism of Action:

• Tenofovir disoproxil fumarate is a prodrug of tenofovir, which is an analogue of adenosine 5′-monophosphate. Once inside the body, tenofovir is phosphorylated by cellular enzymes to its active form, tenofovir diphosphate. Tenofovir diphosphate competitively inhibits the activity of HIV reverse transcriptase and HBV polymerase, thereby interfering with the replication of the viruses.

Indications:

• Viread (tenofovir disoproxil fumarate) is indicated for the treatment of:
  • HIV Infection: It is used in combination with other antiretroviral agents as part of highly active antiretroviral therapy (HAART) for the treatment of HIV-1 infection in adults and pediatric patients aged 2 years and older.
  • Chronic Hepatitis B Virus (HBV) Infection: Viread is also indicated for the treatment of chronic HBV infection in adults.

Dosage:

• The recommended dosage of Viread can vary depending on factors such as the patient’s age, weight, renal function, and other concomitant medications. It is typically taken orally as tablets, with or without food.

Administration:

• Viread tablets should be taken as directed by a healthcare provider. The dosing schedule may involve once-daily dosing or other regimens, depending on the specific treatment protocol and patient factors.

Efficacy:

• Clinical studies have demonstrated the efficacy of tenofovir disoproxil fumarate in reducing HIV viral load and improving CD4 cell counts in patients with HIV-1 infection. It is also effective in suppressing HBV replication and reducing liver inflammation in patients with chronic HBV infection.

Side Effects:

• Common side effects of Viread may include nausea, diarrhea, headache, fatigue, dizziness, and abdominal pain. These side effects are usually mild to moderate in severity and may resolve with continued use or dosage adjustment.

Precautions:

• Before starting Viread, patients should inform their healthcare provider about their complete medical history, current medications, and any allergies. It should be used with caution in patients with certain pre-existing medical conditions, such as renal impairment or bone mineral density loss.

Contraindications:

• Viread is contraindicated in individuals with a known hypersensitivity to tenofovir disoproxil fumarate or any of the other components of the medication. It should not be used in combination with certain other medications that may interact with it.

Storage:

• Viread tablets should be stored as per the manufacturer’s recommendations, ensuring proper temperature and handling to maintain their stability.

Compliance:

• Adherence to the prescribed dosage and administration schedule is crucial for achieving the desired therapeutic outcomes with Viread.

Viread (tenofovir disoproxil fumarate) provides an effective treatment option for HIV-1 infection and chronic HBV infection, offering viral suppression and improved clinical outcomes. However, its use should be carefully managed and monitored by qualified healthcare professionals to ensure optimal safety and efficacy for individual patients. Regular monitoring of renal function, liver function, and viral load may be recommended during treatment.