Xeljanz, also known by its generic name tofacitinib, is a medication available in the form of 5 mg tablets. It is a prescription drug used to treat various autoimmune and inflammatory conditions. Here is a comprehensive description of Xeljanz (tofacitinib) 5 mg tablets:

Mechanism of Action: Xeljanz belongs to a class of medications known as Janus kinase (JAK) inhibitors. It works by inhibiting specific enzymes called Janus kinases, which play a crucial role in the inflammatory response. By blocking these enzymes, Xeljanz helps to regulate the immune system and reduce inflammation associated with autoimmune diseases.

Indications: Xeljanz is indicated for several medical conditions, including:

• Rheumatoid Arthritis: It is used for the treatment of moderate to severe rheumatoid arthritis in adults who have not responded well to other disease-modifying antirheumatic drugs (DMARDs).
• Psoriatic Arthritis: Xeljanz is approved for the treatment of active psoriatic arthritis in adults.
• Ulcerative Colitis: It is indicated for the treatment of moderately to severely active ulcerative colitis in adults.

Dosage: The recommended dosage of Xeljanz may vary depending on the specific condition being treated and the patient’s response. It is usually taken orally as a tablet, typically once or twice daily.

Administration: Xeljanz is administered orally, and the tablets can be taken with or without food, as directed by a healthcare provider.

Efficacy: Clinical trials have shown that Xeljanz can effectively reduce the symptoms and inflammation associated with rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis in many patients.

Side Effects: Common side effects of Xeljanz may include upper respiratory tract infections, headache, and gastrointestinal symptoms. More serious side effects, including an increased risk of serious infections, malignancies, and changes in blood cell counts, may occur but are relatively rare.

Precautions: Patients should inform their healthcare provider about their complete medical history, current medications, and any allergies before starting Xeljanz. Regular monitoring and follow-up appointments are essential for assessing the medication’s safety and effectiveness.

Contraindications: Xeljanz is generally contraindicated in individuals with a known hypersensitivity to tofacitinib or any of its components. It should not be used in patients with active severe infections.

Storage: Xeljanz should be stored as per the manufacturer’s recommendations, ensuring proper temperature and handling to maintain its stability.

Compliance: Patients should adhere to their healthcare provider’s recommendations regarding the use of Xeljanz to achieve the best therapeutic outcomes.

Xeljanz (tofacitinib) 5 mg tablets offer a valuable treatment option for individuals with autoimmune and inflammatory conditions, particularly when other treatments have proven insufficient. It is crucial to consult with a qualified healthcare provider for a thorough evaluation and a personalized treatment plan before using this medication, as they can provide specific guidance based on individual health needs and circumstances.