Description

Zegalogue (dasiglucagon) is a synthetic glucagon receptor agonist used to treat severe hypoglycemia (very low blood sugar) in adults and children ages 6 years and older with diabetes. Glucagon is a hormone that raises blood sugar levels by stimulating the liver to release glucose.

Uses

Zegalogue is used to treat severe hypoglycemia (blood sugar level below 54 mg/dL), which is a life-threatening condition that can cause coma and death. Severe hypoglycemia can occur in people with diabetes who use insulin or other diabetes medications, such as sulfonylureas.

How to Use

Zegalogue is a single-dose injection that is administered subcutaneously (under the skin). It is given to people who are unable to help themselves due to severe hypoglycemia. Zegalogue should be administered by a trained healthcare professional, friend, family member, or caregiver.

Dosage

The recommended dosage of Zegalogue is 0.6 mg. If there is no response to the first dose after 15 minutes, a second dose of 0.6 mg may be administered.

Mechanism of Action

Zegalogue activates glucagon receptors in the liver, which stimulates the breakdown of glycogen and release of glucose into the bloodstream. This raises blood sugar levels and corrects hypoglycemia.

Storage Conditions

Zegalogue should be stored in the refrigerator at 36°F to 46°F (2°C to 8°C). It should not be frozen.

Precautions

Zegalogue should be used with caution in people with the following conditions:

• Adrenal gland tumors
• Pancreatic tumors called insulinomas
• High blood pressure
• Heart disease
• Kidney disease
• Liver disease
• Pregnancy and breastfeeding

Interactions

Zegalogue may interact with other medications, including:

• Insulin
• Sulfonylureas
• Other diabetes medications
• Beta-blockers
• ACE inhibitors
• Angiotensin II receptor blockers
• Diuretics
• Steroids

Contraindications

Zegalogue is contraindicated in people with:

• A known allergy to dasiglucagon
• Pheochromocytoma (a rare tumor of the adrenal gland)
• Insulinoma (a rare tumor of the pancreas)

Side Effects

The most common side effects of Zegalogue are:

• Nausea
• Vomiting
• Diarrhea
• Headache
• Abdominal pain
• High blood pressure
• Allergic reactions

Overdose

An overdose of Zegalogue can cause the following symptoms:

• High blood pressure
• Nausea
• Vomiting
• Diarrhea
• Headache
• Abdominal pain
• Allergic reactions

If you experience any of these symptoms after taking Zegalogue, seek medical attention immediately.

Additional Information

Zegalogue is a prescription medication that is available as a single-dose injection. It is important to talk to your healthcare provider to determine if Zegalogue is right for you and to learn more about the risks and benefits of this medication.