Chemical name: 1-((3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine
Formula: C22H30N6O4S
Anabolic activity index: not a steroid
Androgenic activity index: not a steroid

ZENEGRA-50

Introduction

ZENEGRA-50 is a pharmaceutical medication formulated with the active ingredient Sildenafil Citrate. It belongs to a class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors and is primarily used to treat erectile dysfunction (ED) in men. Erectile dysfunction, often referred to as impotence, is the inability to achieve or maintain an erection sufficient for satisfactory sexual performance. ZENEGRA-50 offers a reliable solution for men experiencing this condition by enhancing blood flow to the penis, thereby facilitating an erection when sexually aroused.

How ZENEGRA-50 Works

The active ingredient in ZENEGRA-50, Sildenafil Citrate, works by inhibiting the PDE5 enzyme. This enzyme is responsible for the breakdown of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum, a spongy tissue found in the penis. cGMP is a critical molecule that helps relax blood vessels and smooth muscle tissue, promoting increased blood flow to the penis during sexual stimulation. By inhibiting PDE5, ZENEGRA-50 enhances the effects of nitric oxide, a natural chemical in the body that dilates blood vessels, thus improving blood flow and aiding in achieving and maintaining an erection.

Indications and Usage

ZENEGRA-50 is indicated for use in men who are experiencing erectile dysfunction. It is effective in helping men achieve and sustain an erection for successful sexual intercourse. ZENEGRA-50 should only be used when there is an intent for sexual activity. It is not intended for continuous daily use and should not be taken more than once per day.

Dosage and Administration

The recommended starting dose of ZENEGRA-50 for most men is 50 mg, taken approximately one hour before sexual activity. However, the tablet can be taken anywhere from 30 minutes to 4 hours prior to sexual intercourse. The effectiveness of ZENEGRA-50 can be influenced by the consumption of food; taking it on an empty stomach may lead to a faster onset of action. It is important to note that sexual stimulation is required for ZENEGRA-50 to be effective.

Mechanism of Action

Sildenafil Citrate, the active ingredient in ZENEGRA-50, functions by blocking the PDE5 enzyme in the penile tissues. During sexual stimulation, nitric oxide is released in the corpus cavernosum, which in turn stimulates the production of cGMP. cGMP is responsible for relaxing smooth muscles and increasing blood flow to the penis. By inhibiting PDE5, ZENEGRA-50 prevents the degradation of cGMP, ensuring that more of this molecule remains in the penis to promote blood flow and facilitate erection.

Potential Benefits

• Effective Treatment for Erectile Dysfunction: ZENEGRA-50 is a well-established medication for treating erectile dysfunction, providing relief for millions of men globally.
• Improved Sexual Confidence: By aiding in the achievement and maintenance of an erection, ZENEGRA-50 helps restore sexual confidence and performance.
• Rapid Onset of Action: The effects of ZENEGRA-50 can be observed within 30 minutes to an hour, making it a convenient option for spontaneous sexual activity.
• Short Half-life: With a half-life of about 4 hours, ZENEGRA-50 provides temporary effects, reducing the risk of prolonged side effects.

Precautions and Warnings

Before using ZENEGRA-50, it is essential to consult a healthcare provider, especially if you have any underlying medical conditions or are taking other medications. Some important considerations include:

• Cardiovascular Risk: Men with cardiovascular conditions should exercise caution when using ZENEGRA-50, as sexual activity may exert additional strain on the heart. Those with severe heart or liver problems should avoid this medication.
• Hypotension: ZENEGRA-50 can cause a temporary drop in blood pressure. It should not be used in conjunction with nitrates or nitric oxide donors as this can result in severe hypotension.
• Priapism: A rare but serious side effect, priapism (prolonged erection lasting more than 4 hours) requires immediate medical attention to prevent damage to the penis.
• Vision and Hearing Impairment: Some users have reported sudden vision or hearing loss after taking PDE5 inhibitors, including Sildenafil. If you experience any such symptoms, seek medical help promptly.

Side Effects

ZENEGRA-50 is generally well-tolerated, but like all medications, it can cause side effects in some individuals. Common side effects include:

• Headache: This is the most frequently reported side effect, experienced by a significant number of users.
• Flushing: A warm or red feeling in the face, neck, or chest may occur.
• Indigestion: Some users may experience stomach discomfort or indigestion.
• Nasal Congestion: Nasal congestion or a runny nose can also occur.
• Visual Disturbances: Changes in color perception, blurred vision, or sensitivity to light are less common but possible side effects.

Contraindications

ZENEGRA-50 is contraindicated in individuals with known hypersensitivity to Sildenafil or any other components of the tablet. It should also not be used by men who are advised against sexual activity due to cardiovascular risk factors or those who are taking nitrates or nitric oxide donors.

Drug Interactions

Several medications can interact with ZENEGRA-50, potentially reducing its effectiveness or increasing the risk of adverse effects. Some notable interactions include:

• Nitrates: Concurrent use of nitrates (such as nitroglycerin) and ZENEGRA-50 can lead to severe hypotension.
• Alpha-blockers: When taken with alpha-blockers, ZENEGRA-50 can cause a significant drop in blood pressure, leading to dizziness or fainting.
• Other PDE5 Inhibitors: Using multiple PDE5 inhibitors together is not recommended and can increase the risk of side effects.
• CYP3A4 Inhibitors: Drugs that inhibit the enzyme CYP3A4 (such as ketoconazole, erythromycin, and ritonavir) can increase the levels of Sildenafil in the blood, enhancing its effects and side effects.

Storage and Handling

ZENEGRA-50 should be stored in its original packaging at room temperature, away from moisture and heat. Keep the tablets out of reach of children and pets. Do not use ZENEGRA-50 after the expiration date printed on the packaging.

Conclusion

ZENEGRA-50 (Sildenafil Tablets IP) is a highly effective treatment for erectile dysfunction, offering men a chance to restore their sexual function and confidence. Manufactured by Alkem Laboratories, a trusted name in pharmaceuticals, ZENEGRA-50 provides a reliable option for men looking to improve their sexual health and quality of life. However, it is important to use this medication under the guidance of a healthcare provider to ensure its safe and effective use.